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Research guide · Metabolic Support

Kisspeptin — research protocol

Hypothalamic neuropeptide studied for its role in regulating GnRH release and reproductive endocrine function.

Evidence boundary

This guide summarizes study areas and sources associated with the compound. BioPeptideX does not convert experimental information into a clinical regimen or recommend an individual dose, frequency, route or duration.

Catalog presentations

10mg5mg15mg20mg

Concentration table

Mathematical reference only; this is not a dosing recommendation.

Resulting concentration5.00 mg/mL
On a U-100 syringe · 1 unit contains0.050 mg

Research areas

  • GnRH/HPG-axis compound
  • Lyophilized powder for stability
  • 99% HPLC verified purity

Most-cited research protocols

Educational information based on research protocols and literature; it does not replace guidance from a healthcare professional.

Kisspeptin is a signaling peptide crucial for the reproductive hormone pathway, telling the brain to release GnRH, which then prompts the pituitary gland to release LH and FSH. Kisspeptin-10 clears quickly, while kisspeptin-54 lasts longer and is commonly used in human trials.

DoseFrequencyDurationRoute
Kisspeptin-10 Low-dose pulse50-100 mcgOnce daily SCN/ASubcutaneous
Kisspeptin-10 Standard pulse100-200 mcgOnce daily SCN/ASubcutaneous
Kisspeptin-10 Split dose100 mcgTwice daily SCN/ASubcutaneous
Kisspeptin-54 IVF oocyte maturation trigger3.2-12.8 nmol/kg single bolusSingle doseN/ASubcutaneous

Cycle: Short pulses or short cycles (e.g., 2-4 weeks active, 2-4 weeks off) are used to avoid desensitization, where continuous exposure can make the signal fade.

Benefits and research observations: Kisspeptin usually produces a fast LH and FSH signal; Kisspeptin-10's LH peak is 30-60 min (SC) with return to baseline in several hours, while Kisspeptin-54's LH peak is ~5 hours (SC) with return to baseline in 12-14 hours. Monitor total testosterone, LH, FSH, and estradiol, along with subjective markers like sleep and mood.

Handling and storage

Store unreconstituted product according to its label and maintain the cold chain where applicable. After any preparation, follow only validated instructions for the specific product and diluent. Do not use if packaging is damaged or the solution shows particles or unexpected changes.

Warnings

Do not use this page for self-diagnosis or self-medication. Pregnancy, breastfeeding, minors, cancer history, allergies, active disease and concurrent treatments require individual professional evaluation.

Published sources

  1. 1.Dhillo WS, et al. JCEM, 2005.
  2. 2.George JT, et al. JCEM, 2011.