Research guide · Recovery & Repair
DSIP — research protocol
Delta Sleep-Inducing Peptide (DSIP) — a small nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) studied for its ability to modulate deep-wave (delta) sleep, normalize circadian rhythm, and buffer stress-induced HPA axis activity.
This guide summarizes study areas and sources associated with the compound. BioPeptideX does not convert experimental information into a clinical regimen or recommend an individual dose, frequency, route or duration.
Catalog presentations
Concentration table
Mathematical reference only; this is not a dosing recommendation.
Research areas
- Modulates delta-wave (deep restorative) sleep architecture
- Studied for normalizing disrupted circadian rhythm and shift-work sleep
- Buffers stress via HPA axis and cortisol modulation
- Neuroprotective profile in preclinical models of oxidative stress
- Investigated as an adjunct for chronic pain and opioid withdrawal research
- Lyophilized powder, 99% HPLC verified purity — COA included
Most-cited research protocols
Educational information based on research protocols and literature; it does not replace guidance from a healthcare professional.
DSIP, or delta sleep-inducing peptide, is a small nine-amino-acid peptide initially isolated from the cerebral venous blood of sleeping rabbits. It is known for promoting delta-wave activity in EEG recordings, which marks deep non-REM sleep.
| Dose | Frequency | Duration | Route | |
|---|---|---|---|---|
| Older human trials | 25 nmol/kg | single evening dose 1-3 hours before intended sleep | 4-7 nights | IV |
| Lower research planning | 100-200 mcg | single evening dose 1-3 hours before intended sleep | short cycles | SubQ |
| Higher research planning | 200-300 mcg | single evening dose 1-3 hours before intended sleep | short cycles | SubQ |
Cycle: Short course (5-7 nights), Standard cycle (4 weeks), or Extended cycle (6-8 weeks)
Benefits and research observations: Subjective sleep changes are often reported on nights 1-2. By week 1, sleep architecture and daytime alertness can be measured, with week 4 being a typical review point.
Handling and storage
Store unreconstituted product according to its label and maintain the cold chain where applicable. After any preparation, follow only validated instructions for the specific product and diluent. Do not use if packaging is damaged or the solution shows particles or unexpected changes.
Warnings
Do not use this page for self-diagnosis or self-medication. Pregnancy, breastfeeding, minors, cancer history, allergies, active disease and concurrent treatments require individual professional evaluation.
Published sources
- 1.Schneider-Helmert D, Schoenenberger GA. Experientia, 1983.
- 2.Sudakov KV, et al. Bull Exp Biol Med, 2004.
- 3.Khvatova EM, et al. Ann N Y Acad Sci, 2005.